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These data collectively suggest that the inhibitory effect of GSSG on the NF-B signaling pathway, via suppression of IKK- activation, is mechanistically implicated in the increased sensitivity of hepatocytes to TNF killing

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The activation-inactivation mechanism of GPX4 is currently unknown, but high activity evidence on differentiated spermatogenic cell membranes suggests that there may be some link between cell differentiation and peroxide levels

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